Currently showing only Plant & Animal Breeding Resources
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Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals

Publication date: 26/11/2018

The human population is growing, and as a result we need to produce more food whilst reducing the impact of farming on the environment. Selective breeding and genomic selection have had a transformational impact on livestock productivity, and now transgenic and genome-editing technologies offer exciting opportunities for the production of fitter, healthier and more-productive livestock. Here, we review recent progress in the application of genome editing to farmed animal species and discuss the potential impact on our ability to produce food.

Resource type: Adobe Acrobat (.pdf)

Bound to fail: The flawed scientific foundations of agricultural genetic engineering

Publication date: 21/11/2018

Many technologies, at the time of their inception, have appeared efficacious, safe, and generally a good idea, based on the science at the time. However, in a number of cases, a technology that was once deemed appropriate and desirable has later turned out to be not such a good idea after all. Not only has it failed to deliver on its promises, but it has given rise to environmental damage and negative health impacts. Such technologies have ended up being abandoned or tightly restricted.

There are many examples from history. Asbestos, DDT insecticides, leaded gasoline, and PCBs (polychlorinated biphenyls) in electrical goods were all once hailed as great innovations, but as we grew in our understanding of the mechanisms and complexities of nature’s functioning, we found they could have devastating effects on the health of humans and animals.

We continue to learn from our catastrophic mistakes, but only after serious damage has already occurred to health and the environment. In order to avoid such damage, we need to constantly review each technology from the perspective of the science from which it is derived. Transgenic and genome editing technologies are no exception.

Resource type: article: Web Page

Organic GMOs – ask yourself, can this ever be a ‘thing’?

Publication date: 10/11/2018

There is no question that our food system is broken. The way we farm, the way we process, sell, buy and eat food has become an exercise in a polluted environment and polluted, undernourished bodies.

Against this backdrop the word ‘organic’ is sometimes waived like a flag – or worn like a magic cloak – that protects us from harm.

The image of organic, of an agricultural system that promotes healthy plants, animals, soil and humans; that emulates and sustains natural systems; that promotes fairness and justice for all living things; and that cares for future generations, is still strong and is still substantially true.

Organic is the most widely-used system that comes closest in practice to genuinely sustainable farming. But it’s under attack on many fronts. In part this is because there can be a large space between image and the business-as-usual reality of food production. Even with the best will in the world, unsatisfactory practices can creep in and, increasingly, corporate and industrial farming and food interests seek to benefit financially from the cache of organic while at the same time belittling, and in some cases ignoring, its core values.

As in many things the US leads the way in this. Hydroponics and concentrated animal feeding operations (CAFOs) have both been allowed in organic foods certified by the United States Department of Agriculture (USDA), in the face of considerable opposition, recently formalised under the banner of the Real Organic Project.

The US has also been blighted by the rise what some call ‘Big Organic’ – an upscaling of organic production that mimics industrial agriculture in its reliance on monocultures, intensive animal rearing and industrial processes. One component of Big Organic is some of the well-established organic brands that have been bought up by large food conglomerates; another is the proliferation of ‘organic’ supermarkets that operate in the same unfair and unsustainable way as their conventional counterparts.

It might be argued that this is simply the consequence of continued and healthy growth in the organic market. Even if that is the case, it is also part of a subtle trend that chips away at the essential nature of organic using mumbo jumbo about the inevitability of market forces and opaque certification.

Resource type: article: Web Page

Policy and governance perspectives for regulation of genome edited crops in the United States

Publication date: 08/11/2018

Genome editing for crop improvement lies at the leading edge of disruptive bioengineering technologies that will challenge existing regulatory paradigms for products of biotechnology and which will elicit widespread public interest.

Regulation of products of biotechnology through the US Coordinated Framework for Biotechnology is predicated on requiring burden of proof that regulation is warranted. Although driven by considerations of newly emerging processes for product development, regulation has, for the most part, focused on characteristics of the biotechnology product itself and not the process used for its development per se.

This standard of evidence and product focus has been maintained to date in regulatory considerations of genome edited crops. Those genome edited crops lacking recombinant DNA (rDNA) in the product intended for environmental release, lacking plant pest or pesticidal activity, or showing no food safety attributes different from those of traditionally bred crops are not deemed subject to regulatory evaluation.

Regardless, societal uncertainties regarding genome editing are leading regulators to seek ways whereby these uncertainties may be addressed through redefinition of those products of biotechnology that may be subject to regulatory assessments. Within US law prior statutory history, language and regulatory action have significant influence on decision making; therefore, the administrative law and jurisprudence underlying the current Coordinated Framework strongly inform policy and governance when considering new plant breeding technologies such as genome editing.

Our purpose in this discussion has been to elaborate how governance within the US legal framework is influencing decisions regarding the regulation of genome edited crops. We do not defend or justify the US regulatory system or suggest any given theory of jurisprudence which is preferable for administration of the Coordinated Framework for Biotechnology. Such considerations would require much more serious examination of the norms that constitute the basis of the US regulatory system.

However, this analysis of the regulatory framework for biotechnology in the US should provide an explanation of the circumstances in law that have led US regulatory agencies, including the USDA, to their current positions for imposing new rules for crops and derived foods developed through genome editing.

Open access .pdf also available.

Resource type: article: Web Page

Organic farming with gene editing: An oxymoron or a tool for sustainable agriculture?

Publication date: 10/10/2018

A University of California, Berkeley professor stands at the front of the room, delivering her invited talk about the potential of genetic engineering. Her audience, full of organic farming advocates, listens uneasily. She notices a man get up from his seat and move toward the front of the room. Confused, the speaker pauses mid-sentence as she watches him bend over, reach for the power cord, and unplug the projector. The room darkens and silence falls. So much for listening to the ideas of others.

Many organic advocates claim that genetically engineered crops are harmful to human health, the environment, and the farmers who work with them. Biotechnology advocates fire back that genetically engineered crops are safe, reduce insecticide use, and allow farmers in developing countries to produce enough food to feed themselves and their families.

Now, sides are being chosen about whether the new gene editing technology, CRISPR, is really just “GMO 2.0” or a helpful new tool to speed up the plant breeding process. In July, the European Union’s Court of Justice ruled that crops made with CRISPR will be classified as genetically engineered. In the United States, meanwhile, the regulatory system is drawing distinctions between genetic engineering and specific uses of genome editing.

Resource type: article: Web Page

Towards resilience through systems-based plant breeding. A review

Publication date: 22/08/2018

How the growing world population can feed itself is a crucial, multi-dimensional problem that goes beyond sustainable development. Crop production will be affected by many changes in its climatic, agronomic, economic, and societal contexts. Therefore, breeders are challenged to produce cultivars that strengthen both ecological and societal resilience by striving for six international sustainability targets: food security, safety and quality; food and seed sovereignty; social justice; agrobiodiversity; ecosystem services; and climate robustness.

Against this background, we review the state of the art in plant breeding by distinguishing four paradigmatic orientations that currently co-exist: community-based breeding, ecosystem-based breeding, trait-based breeding, and corporate-based breeding, analyzing differences among these orientations. Our main findings are: (1) all four orientations have significant value but none alone will achieve all six sustainability targets; (2) therefore, an overarching approach is needed: “systems-based breeding,” an orientation with the potential to synergize the strengths of the ways of thinking in the current paradigmatic orientations; (3) achieving that requires specific knowledge development and integration, a multitude of suitable breeding strategies and tools, and entrepreneurship, but also a change in attitude based on corporate responsibility, circular economy and true-cost accounting, and fair and green policies.

We conclude that systems-based breeding can create strong interactions between all system components. While seeds are part of the common good and the basis of agrobiodiversity, a diversity in breeding approaches, based on different entrepreneurial approaches, can also be considered part of the required agrobiodiversity. To enable systems-based breeding to play a major role in creating sustainable agriculture, a shared sense of urgency is needed to realize the required changes in breeding approaches, institutions, regulations and protocols. Based on this concept of systems-based breeding, there are opportunities for breeders to play an active role in the development of an ecologically and societally resilient, sustainable agriculture.

Resource type: Adobe Acrobat (.pdf)

What is the available evidence for the application of genome editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map protocol

Publication date: 16/08/2018

Plant breeding is a developing process and breeding methods have continuously evolved over time. In recent years, genome editing techniques such as clustered regularly interspaced short palindromic repeats/CRISPR associated proteins (CRISPR/Cas), transcription activator-like effector nucleases (TALENs), zinc-finger nucleases (ZFN), meganucleases (MN) and oligonucleotide-directed mutagenesis (ODM) enabled a precise modification of DNA sequences in plants. Genome editing has already been applied in a wide range of plant species due to its simplicity, time saving and cost-effective application compared to earlier breeding techniques including classical mutagenesis. Although genome editing techniques induce much less unintended modifications in the genome (off-target effects) compared to classical mutagenesis techniques, off-target effects are a prominent point of criticism as they might cause genomic instability, cytotoxicity and cell death.

Resource type: Adobe Acrobat (.pdf)

Who’s talking about non-human Genome Editing? Mapping public discussion in the UK

Publication date: 31/05/2018

This report reviews public discussion about Genome Editing in non-human organisms. Its primary goal is to provide a preliminary baseline regarding the kinds of public discussion about, and interactions with, a development in biotechnology with societal significance.

Previous research and experience governing emerging technologies has shown that they need to be developed in ways that are ethical, safe and accountable, that deliver meaningful public value and that foster public trust in democratic institutions. Past experience in Britain suggests public deliberation and discourse has a vital role to play in developing effective governance arrangements and the nation has developed significant institutional expertise in developing such arrangements.

To date, attention has focused largely on the use of Genome Editing in humans. For instance, in 2015 an international summit produced a consensus statement on human Genome Editing. This was followed by a consensus study by the US National Academies of Sciences, Engineering, and Medicine into the ethics and governance of human Genome Editing, published in 2017. However, Genome Editing techniques span virtually all domains of bioscience and biotechnology that rely on altering genetic sequences. In today’s landscape, this means their envisaged uses in both scientific research, as tools, and in developing new technologies or commercially-valuable processes are widespread. It is therefore vital that non-human applications are considered.

In the UK, the Nuffield Council on Bioethics recently concluded an initial study on the ethics of Genome Editing and is undertaking follow up studies on human Genome Editing and Genome Editing in livestock. The Wellcome Trust is currently funding public engagement on Genome Editing as applied to human health and medicine through the Genome Editing Public Engagement Synergy with the National Coordinating Centre for Public Engagement. This review complements the above work by providing baseline information about public discussion of, and public engagement with, Genome Editing in non-human contexts.

Resource type: Adobe Acrobat (.pdf)

Compatibility of breeding techniques in organic systems

Publication date: 01/01/2018

This IFOAM position paper states that “New genetic engineering technologies …are not compatible with organic farming and must not be used in organic breeding or organic production.” It goes on to list the specific techniques, and calls for “clear legal definitions to be in place which are regularly updated”.

The paper also states “Products obtained through genetic engineering processes should not be released into the environment. In any case such releases should not take place without a prior rigorous, multistakeholder designed and agreed risk assessment protocol that includes input from the organic sector and like-minded movements, and an assessment of the possibility to prevent the presence of such products in organic products and GMO-free products.”

IFOAM asks for the ‘Polluter Pays’ principle to be maintained. This means “On-going costs and harms to organic and non-GMO supply chains from contamination by these new techniques … should be borne by the developers and/or the company that puts the product on the market.” Although the principle is one of the EU directives, sadly it is not guaranteed in post-Brexit Britain.

Resource type: article: Web Page

Perspectives on organic agriculture and new plant breeding techniques

Publication date: 08/11/2017

The organic industry has vocally rejected genetically-modified crops (GMOs), making a public declaration in 1993 that they are incompatible with organic agriculture.

Since then, many organic supporters have campaigned against GMOs, and organic farming regulations in the EU and beyond prohibit their use.

Emerging genetic technologies have sparked renewed interest in this debate, but policy makers are still undecided on whether they should be subject to the same extensive regulations as genetic modification. Within the organic industry, there are different perspectives on whether these new techniques could ever be compatible with organic food production.

In this blog-post Rebecca Nesbit gives us an insight into these differing perspectives, interviewing proponents from each side.

Resource type: article: Web Page