Rés0Pest implemented cropping systems that excluded all pesticide use, including seed treatments, while maintaining synthetic fertilizer inputs. The systems were co-designed through participatory methods, following a system experiment approach that evaluates the effects of a combination of cropping practices and their interactions on cropping system performance over the long term. Results showed that in pesticide-free systems, it is possible to achieve yields comparable to conventional and higher than organic systems and, in some cases, generate higher net farm income. Pest and pathogen crop damage did not significantly increase over time, although weed management remained a key challenge. These findings suggest that technically and economically viable pesticide-free arable systems are possible under certain conditions, and that new solutions are needed to support their adoption across a wider range of contexts.