Abstracts, Papers &
Resources:
Science & Technology
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Gene Editing: the Ethical Questions
This blog employs a food ethics lens to delve into some of the ethical issues surrounding gene-editing, assessing intended and unintended consequences. Issues discussed include patents, herbicide-tolerant traits, gene drives and food safety.
Beyond the Genome: Genetically Modified Crops in Africa and the Implications for Genome Editing
This article makes two interventions. First, it identifies the discursive continuity linking genome editing and the earlier technology of genetic modification. Second, it offers a suite of recommendations regarding how lessons learned from GM crops might be integrated into future breeding programmes focused on genome editing. Ultimately, the authors argue that donors, policymakers and scientists should move beyond the genome towards systems-level thinking by prioritizing the co-development of technologies with farmers; using plant material that is unencumbered by intellectual property restrictions and therefore accessible to resource-poor farmers; and acknowledging that seeds are components of complex and dynamic agroecological production systems. If these lessons are not heeded, genome-editing projects are in danger of repeating mistakes of the past
Unintended Genomic Outcomes in Current and Next Generation GM Techniques: A Systematic Review
Here, we systematically review the scientific literature for studies that have investigated unintended genomic alterations in plants modified by the following GM techniques: Agrobacterium tumefaciens-mediated gene transfer, biolistic bombardment, and CRISPR-Cas9 delivered via Agrobacterium-mediated gene transfer (DNA-based), biolistic bombardment (DNA-based) and as ribonucleoprotein complexes (RNPs). The results of our literature review show that the impact of such techniques in host genomes varies from small nucleotide polymorphisms to large genomic variation, such as segmental duplication, chromosome truncation, trisomy, chromothripsis, breakage fusion bridge, including large rearrangements of DNA vector-backbone sequences. We have also reviewed the type of analytical method applied to investigate the genomic alterations and found that only five articles used whole genome sequencing in their analysis methods. In addition, larger structural variations detected in some studies would not be possible without long-read sequencing strategies, which shows a potential underestimation of such effects in the literature. As new technologies are constantly evolving, a more thorough examination of prospective analytical methods should be conducted in the future.
Gene Drives in the UK, US, and Australian Press (2015–2019): How a New Focus on Responsibility Is Shaping Science Communication
The complexity of the gene and the precision of CRISPR: What is the gene that is being edited?
Precision Technologies for Agriculture: Digital Farming, Gene-Edited Crops, and the Politics of Sustainability
This article analyzes the rise of precision technologies for agriculture—specifically digital farming and plant genome editing—and their implications for the politics of environmental sustainability in the agrifood sector. We map out opposing views in the emerging debate over the environmental aspects of these technologies: while proponents see them as vital tools for environmental sustainability, critics view them as antithetical to their own agroecological vision of sustainable agriculture. We argue that key insights from the broader literature on the social effects of technological change—in particular, technological lock-in, the double-edged nature of technology, and uneven power relations—help to explain the political dynamics of this debate. Our analysis highlights the divergent perspectives regarding how these technologies interact with environmental problems, as well as the risks and opportunities they present. Yet, as we argue in the article, developments so far suggest that these dynamics are not always straightforward in practice.
Democratizing CRISPR? Stories, practices, and politics of science and governance on the agricultural gene editing frontier
European science community urges rethink on genome editing
Scientists from the John Innes Centre and The Sainsbury Laboratory today joined colleagues from across Europe in calling for an urgent rethink of EU legislation on Genetically Modified Organisms (GMOs).
An open statement signed by 126 research institutes says that scientists and plant breeders in the European Union should be enabled to use gene editing with CRISPR as a faster and more efficient way of producing food sustainably.
Aimed at the newly-elected European Parliament and European Commission, the statement comes one year to the day that the European Court of Justice (ECJ) ruled that plants obtained by modern forms of mutagenesis, of which gene-editing is an example, are not exempted from the EU GMO Directive.
Gene Drives. A report on their science, applications, social aspects, ethics and regulations
This lengthy and in-depth report – a collaboration by Critical Scientists Switzerland (CSS), European Network of Scientists for Social and Environmental Responsibility (ENSSER) and Vereinigung Deutscher Wissenschaftler (VDW) – delves into the science, biology and techniques behind gene drives, their potential applications and risks, as well as the social, ethical legal and regulatory issues that the technology, perhaps inevitably, brings with it.