Summary
A central concern about achieving global food security is reconfiguring agri-food systems towards sustainability. However, historically-informed trajectories of agri-food system development remain resistant to a change in direction. Through a systematic literature review, we identify three research domains exploring this phenomenon and six explanations of resistance: embedded nature of technologies, misaligned institutional settings, individual attitudes, political economy factors, infrastructural rigidities, research and innovation priorities. We find ambiguities in the use of the terms lock-in and path-dependency, which often weaken the analysis. We suggest a framing that deals with interdependencies and temporal dynamics of causes of resistance. Finally, we discuss implications for framing innovation for transformational change and other research gaps.