Simulation of dual-purpose chicken breeding programs implementing gene editing

Summary

The paper considered the possibility of using gene editing to accelerate progress towards dual purpose chickens, thus eliminating the need for male culling. Our simulation demonstrated a general increase in genetic gain when genomic selection is used together with GE. The overall benefit of GE erased after some generations because the large-effect alleles became fixed. Hence, GE could be beneficial only when alleles with reasonable effect sizes are segregating and detectable. When the consumer preference and the price difference between the genome-edited chicken and the other chickens were to be considered, the findings from this study might not be sufficient to recommend the use of GE in breeding programs for quantitative traits.”